This issue of Emergency Medicine Clinics, guest edited by Drs. Mimi Lu, Ilene Claudius and Chris Amato, focuses on Pediatric Emergency Medicine. This is one of four issues each year selected by the series consulting editor, Dr. Amal Mattu. Articles in this issue include, but are not limited to: High-risk medicolegal issues in PEM: meningitis, appendicitis, fractures, Respiratory Emergencies: intubation, non-invasive, trach emergencies , supraglottic airways, Neck Trauma: cervical spine, seatbelt signs, penetrating palate injuries, Cardiac Emergencies, Fever and Tox: New Designer Drugs.