In this issue of Clinics in Laboratory Medicine, guest editor Dr. Marisa C. Neilsen brings her considerable expertise to the topic of Infectious Disease Diagnostics. Top experts discuss current guidelines for infectious diseases diagnostics and emerging technology in the field of clinical microbiology; cover the strengths and weaknesses of current testing strategies and how laboratory results are used to guide treatment and improve patient outcomes; and explore how laboratories can adapt to the dynamic endemicity of pathogens, increasing antimicrobial resistance, and pandemics.